Alda-1, ≥98%
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| CAS | 349438-38-6 |
|---|---|
| 英文名称 | Alda-1 |
| 纯度 | ≥98% |
| 分子量 | 324.16 |
| 外观（性状） | White to off-white Solid |
| 储存条件 | Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months |
| 溶解性 | Soluble in DMSO |
| MDL | MFCD02055160 |
| InChIKey | NMKJFZCBCIUYHI-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H11Cl2NO3/c16-10-2-1-3-11(17)14(10)15(19)18-7-9-4-5-12-13(6-9)21-8-20-12/h1-6H,7-8H2,(H,18,19) |
| PubChem CID | 831629 |
| SMILES | O=C(NCC1=CC=C(OCO2)C2=C1)C3=C(Cl)C=CC=C3Cl |
| 描述 | Alda-1是一种ALDH2激动剂。(Alda-1 is an ALDH2 agonist.) |
| 靶点 | Aldehyde Dehydrogenase (ALDH) |
| 通路 | Metabolic Enzyme&Protease |
| 生物活性 | Alda-1 is an ALDH2 agonist, a cell-permeable activator of both the wild-type ALDH2*1 and the Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2).[1-2] |
| In Vitro | Alda-1 alleviated liver injury after hepatic I/R. Pretreatment with Alda-1 significantly alleviated I/R-induced elevations of alanine aminotransferase and aspartate aminotransferase, and significantly blunted the pathological injury of the liver. Moreover, Alda-1 significantly inhibited ROS and proinflammatory cytokines production, 4-HNE and MDA accumulation, and apoptosis. Increased ALDH2 activity was found after Alda-1 administration. No significant changes in ALDH2 expression were observed after I/R[2]. |
| 细胞实验 | Animal Models: Male Sprague-Dawley rats (IR model); Dosages: 10 mg/kg; Administration: i.p.[2] |
| 动物实验 | The H/R (Hypoxia/reoxygenation) group cells are incubated under a hypoxic atmosphere (95% N2+5% CO2) for 6 h followed by 120 min reoxygenation (95% air + 5% CO2). The control incubation is normoxic conditions (95% air + 5% CO2) for the entire experiment. In the H/R+Alda-1 group, cells are incubated with Alda-1 (20 μM) for 60 min at 37℃ (95% air/5% CO2) before exposure to hypoxia. Furthermore, BRL-3A cells are treated with 5 μM 4-HNE for 60min before exposure to hypoxia to estimate whether 4-HNE could affect H/R.[2] |
| 数据来源文献 | [1] Samantha Perez-Miller, et al. Nat Struct Mol Biol. 2010, 17(2): 159-164. |
| 规格 | 5mg10mg |
| 单位 | 瓶 |
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