Recombinant human TRPM8 protein
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| 基因名 | TRPM8 |
|---|---|
| 英文全称 | transient receptor potential cation channel, subfamily M, member 8 |
| 别称 | TRPM8; LTRPC6; TRPP8; transient receptor potential cation channel subfamily M member 8 |
| 中文名称 | 瞬时受体电位阳离子通道M亚家族成员8 |
| Uniprot | Q7Z2W7 |
| GeneID | 79054 |
| 交叉反应(推测) | Human Mouse Rat |
| 氨基酸大小 | 23kDa |
| 表达氨基酸 | 1-192aa |
| Background | Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius.Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH.Involved in menthol sensation.Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium.Temperature sensing is tightly linked to voltage-dependent gating.Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves.The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials.Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity.Plays a role in prostate cancer cell migration .Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel. |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Urea, Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| Bioactive | Not tested. |
| Tag information | With a 6His tag at the N-terminus. |
| 单位 | 支 |
| 规格 | 10ug50ug100ug1mg |
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