Recombinant human NR0B2 protein
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| 基因名 | NR0B2 |
|---|---|
| 英文全称 | nuclear receptor subfamily 0, group B, member 2 |
| 别称 | NR0B2; NR0B2_HUMAN; Nr0b2a; Nuclear receptor subfamily 0 group B member 2; Nuclear receptor subfamily 0, group B, member 2a; Orphan nuclear receptor SHP; SHP; SHP-1; Shp1; Small heterodimer partner; |
| 中文名称 | 核受体亚家族0,B组成员2 |
| Uniprot | Q15466 |
| GeneID | 8431 |
| 交叉反应(推测) | Human Mouse Rat |
| 氨基酸大小 | 29kDa |
| 表达氨基酸 | 1-257aa |
| Background | Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (By similarity).Specifically inhibits transactivation of the nuclear receptor with which it interacts (By similarity).Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (PubMed:14752053).Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (By similarity).Regulates the circadian expression of cytochrome P450 (CYP) enzymes (By similarity).Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14 (By similarity). |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Urea, Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| Endotoxin | / |
| Bioactive | Not tested. |
| Tag information | With a 6His tag at the N-terminus. |
| 单位 | 支 |
| 规格 | 10ug50ug100ug1mg |
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