Rac1 G15A Agarose Beads (Active Rac-GEF) (ab211184)
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| 产品名称 | Rac1 G15A Agarose Beads (Active Rac-GEF) |
|---|---|
| 品牌 | 艾博抗Abcam |
| 货号 | ab211184 |
| 产品概述 | Background: Small GTP-binding proteins (or GTPases) are a family of proteins that serve as molecular regulators in signaling transduction pathways. Rac, a 21 kDa protein, belongs to the family of Rho GTPases regulating a variety of biological response pathways that include cell motility, cell division, gene transcription, and cell transformation. Like other small GTPases, Rac influences molecular events by cycling between an inactive GDP-bound form and an active GTP-bound form. Cycling between the GDP-bound and GTP-bound state is regulated primarily by two distinct families of proteins: guanine nucleotide exchange factors (GEFs) activate Rho proteins by catalyzing the exchange of GDP for GTP, the GTPase activating proteins or GAPs negatively regulate GTPase function by stimulating GTP hydrolysis.Similar to Ras mutants, constitutively active or dominant negative Rho GTPase mutants have been used to bind to Rho-GAP and effectors or to Rho-GEFs, respectively. A nucleotide-free GTPase has also been shown to form a high affinity binary complex with Rho-GEFs. Rac1 G15A Agarose beads selectively isolate and pull-down the active form of Rac-GEFs from purified samples or endogenous lysates. Subsequently, the precipitated Rac-GEF is detected by western blot analysis using an anti-Rac-GEF antibody.Use: Our Rac1 G15A Agarose Beads are designed to pull down only the active form of Rac1-GEF.Description: Our Rac1 G15A Agarose beads, in color, are easy to visualize, minimizing potential loss during washes and aspirations of active Rac-GEF pulldown.Purity and Activity: Purity >90% by SDS-PAGE and Coomassie blue staining. Specifically interacts and precipitaes active Rac-GEF from cell lysate.Concentration: 800 μL of 50% Agarose slurry, 1 mg/mL Rac1 G15A in 1X PBS, 50% Glycerol |
| 研究领域 | Signal Transduction Signaling Pathway G Protein Signaling Small G Proteins Ras Family Cancer Signal transduction G protein signaling Small G proteins Ras family Immunology Innate Immunity TLR Signaling |
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